Technique Could Help To Identify Novel Antibacterial Targets

Can the microRNA expression profile help to identify novel targets for zoledronic acid in breast cancer?

Zoledronic acid (ZOL), belonging to third generation bisphosphonate family, is a potent inhibitor of osteoclast-mediated bone resorption, widely used to effectively prevent osteolysis in breast cancer patients who develop bone metastases. Low doses of ZOL have been shown to exhibit a direct anticancer role, by inhibiting cell adhesion, invasion, cytoskeleton remodelling and proliferation in MCF...

A Riboproteomic Platform to Identify Novel Targets for Prostate Cancer Therapy A Riboproteomic Platform to Identify Novel Targets for Prostate Cancer Therapy”

Blood-Based Biomarkers Could Help Identify Subclinical Brain Damage Caused by Arterial Hypertension

Arterial hypertension is the most prevalent non-communicable disease worldwide, and has long been recognized as a major risk factor for cardiovascular and cerebrovascular diseases. High blood pressure has deleterious consequences on the main target organs (heart, kidney, brain), and several studies have shown that brain damage is more frequent than heart and kidney involvement. Silent lesions c...

Protein Interactions in Genome Maintenance as Novel Antibacterial Targets

Antibacterial compounds typically act by directly inhibiting essential bacterial enzyme activities. Although this general mechanism of action has fueled traditional antibiotic discovery efforts for decades, new antibiotic development has not kept pace with the emergence of drug resistant bacterial strains. These limitations have severely restricted the therapeutic tools available for treating b...

Could interferon help treat Ebola?